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FAECALIBACTERIUM PRAUSNITZII: THE “MYSTERIOUS” PROBIOTIC INFLUENCING MENTAL HEALTH

FAECALIBACTERIUM PRAUSNITZII: THE “MYSTERIOUS” PROBIOTIC INFLUENCING MENTAL HEALTH

11/09/2025

It's surprising to many that mood swings, anxiety, or depression can originate from the gut itself. Among the thousands of types of bacteria living in the digestive system, Faecalibacterium prausnitzii stands out as an important probiotic with anti-inflammatory capabilities, protecting the intestinal lining, and influencing the production of serotonin – a neurotransmitter that regulates emotions.

Numerous studies indicate that a deficiency of this bacterium may be linked to mental disorders and intestinal diseases. Could this be the "happiness probiotic" that we are overlooking? 

What is Faecalibacterium prausnitzii?  

According to M.Sc. Dr. Mai Vien Phuong – Head of the G.I Endoscopy Unit at AIH, Faecalibacterium prausnitzii (F. prausnitzii) is one of the most common and important beneficial bacteria in the human gut microbiota, primarily residing in the large intestine.

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Faecalibacterium prausnitzii (F. prausnitzii) is one of the most common and important beneficial bacteria in the human gut microbiota.

The primary role of Faecalibacterium prausnitzii in the body 

According to recent researchs: 

The production of butyrate – a golden nutrient for a healthy colon

Faecalibacterium prausnitzii produces butyrate, a short-chain fatty acid extremely important for colon cells. This substance nourishes the intestinal lining, effectively reduces inflammation, and strengthens the intestinal barrier, helping to prevent 'leaky gut' – a potential cause of immune disorders and systemic health issues.

Immunomodulation and Anti-inflammatory effects

This bacterium possesses the ability to modulate immune responses and reduce inflammation in both the gut and systemically. Consequently, it plays a protective role against inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.

Impact on mental health

Through its influence on the gut-brain axis, F. prausnitzii can indirectly promote the production of serotonin, a neurotransmitter associated with emotions. The deficiency of this bacterium may be linked to depression, anxiety, and mood disorders.

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A deficiency of the beneficial bacterium Faecalibacterium prausnitzii may be associated with depression, anxiety, and mood disorders.

Maintaining gut microbiota balance

F. prausnitzii contributes to maintaining the diversity and stability of the microbiota by competing with and inhibiting harmful bacteria. This helps to enhance overall gut health.

How to enhance Faecalibacterium prausnitzii levels?

You can support this bacterium by:

  • Eating plenty of fiber (green vegetables, whole grains, legumes, bananas, artichokes, garlic, onions, etc.)

  • Avoiding antibiotic overuse

  • Reducing stress and getting enough sleep

  • Potentially supplementing prebiotics (food for beneficial bacteria) or postbiotics (butyrate)

  • Certain probiotics may indirectly support the growth of F. prausnitzii

Faecalibacterium prausnitzii is not just a 'good bacteria for digestion' but also a silent 'friend' to your mental health. Nurturing your gut microbiome is an important part of protecting your mind.

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Balanced nutrition and a high-fiber diet help increase Faecalibacterium prausnitzii.

When should you get a gut microbiome test?

M.Sc. Dr. Mai Vien Phuong states that although symptoms of emotional or digestive disorders are often underestimated, they can be signs of an imbalance in the gut microbiota – including a decrease in Faecalibacterium prausnitzii. You should seek medical attention if:

  • Experiencing prolonged bloating, abdominal distension, digestive disorders, diarrhea, or constipation.

  • Showing signs of mood swings, anxiety, difficulty sleeping, or mild depression of unknown cause.

  • Having a history of enteritis, irritable bowel syndrome (IBS), ulcerative colitis, or Crohn's disease.

  • Recently undergone a prolonged course of antibiotic treatment.

  • Wanting to proactively check and analyze the gut microbiota for early disease prevention.

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Thạc sĩ, Bác sĩ Mai Viễn Phương tư vấn tầm soát bệnh lý đường tiêu hoá tại AIH

Specialized care for gastrointestinal diseases at American International Hospital (AIH)

The digestive system is the first 'gateway' that determines overall health, from nutrient absorption and immunity to mental health. Understanding this importance, AIH provides comprehensive diagnostic and treatment services for digestive diseases, combining modern technology with in-depth expertise.

  • Experienced medical team, specialized in treating diseases of the stomach – intestines, liver, gallbladder, pancreas, and gut microbiota. 

  • Modern, minimally invasive endoscopic system, helping to detect early digestive lesions even before clear symptoms appear. 

  • Advanced gut microbiota testing, supporting the assessment of beneficial – harmful bacteria, detecting microbial imbalances related to digestion, immunity, and neuropsychology. 

  • Intestinal microbiota analysis and inflammatory marker testing, providing in-depth assessment of gut health and inflammatory responses. 

  • Personalized treatment protocols, helping to restore gut microbiota safely and scientifically. 

  • In-depth consultation on digestive health, psychology – nutrition related to the microbial system, thereby adjusting beneficial behaviors and habits. 

  • Close connection with Psychology and Nutrition department if necessary, ensuring comprehensive and interdisciplinary treatment access.

To register for examination and treatment by M.Sc. Dr. Mai Vien Phuong, kindly contact the hotline (028) 3910 9999 or inbox the Fanpage https://m.me/aih.com.vn.

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AMERICAN INTERNATIONAL HOSPITAL (AIH):
☎ Hotline: (028) 3910 9999
🌏 Website: www.aih.com.vn
📍Address: (Entrance from 199 Nguyen Hoang Street) No.6, Bac Nam 3 Street, Binh Trung Ward, Ho Chi Minh
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Mai Vien Phuong

Mai Vien Phuong

Gastroenterology - Hepatology

MSc. Dr. Mai Vien Phuong is an expert in Gastroenterology – Endoscopy with over 15 years of clinical...